Scott Dixon went from last in qualifying to capture his fourth win at Mid-Ohio in the last six years, coasting in on low fuel to end Target Chip Ganassi Racing's victory drought in 2014.
The 34-year-old New Zealander, who started last in the 22-car field, also won on the twisty road course between Cleveland and Columbus in 2009, 2011 and 2012.
Target Chip Ganassi has won the last six races at the track, including all four of Dixon's triumphs.
It finally broke through in a familiar place. Dixon took advantage of a gaffe by Josef Newgarden and his pit crew to pull away.
Pole-sitter Sebastien Bourdais was a distant second, with James Hinchcliffe third, rookie Carlos Munoz fourth and favorite son Graham Rahal fifth.